3ds Max is the program I feel most comfortable using. I have been using 3ds Max for 5 years now. I can't picture using any other 3D program as heavily as I use 3ds Max. I have grown to love the program over the years.
I purchased my first drawing tablet back in 2013. I had no clue how to use it in conjuction with Photoshop and I absolutely hated it in the beginning. Once I started learning the techniques and became used to navigating around with a tablet it started to grow on me. I am probably not going to become the next best 2D artist but digital painting is definitely a useful tool to have in my tool belt.
I am still very new to Zbrush. There is so much about the program that I know is very useful, I just simply haven't learned it all yet. Zbrush is very intimidating at first with all of it's settings, but I am learning that Zbrush is very, very helpful at time and can be used quite nicely in conjunction with other programs such as 3ds Max.
I used Unity first in my Junior Project class. My group worked on a project with Steelcase. I was in charge of designing the level along with creating small assets with texture maps. The project was made so that busy Steelcase customers could get a feel for Steelcase's chairs without physically being there at the headquarters.